Alternate pathways of DNA replication: DNA polymerase I-dependent replication.

PCNA and DNA replication ( I )

Replication of the entire genome during S-phase is one of the most important cell cycle events and requires the coordinated activity of a multitude of different enzymes. Proliferating cell nuclear antigen (PCNA) interacts directly and indirectly with most of these proteins and thereby plays a leading part in the coordination of the replication process. PCNA is the processivity factor for the re...

Role of yeast DNA polymerase epsilon during DNA replication

Polymerase Dynamics at the Eukaryotic DNA Replication

This review discusses recent insights in the roles of DNA polymerases (Pol) and in eukaryotic DNA replication. A growing body of evidence specifies Pol as the leading strand DNA polymerase and Pol as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mutator phenotype for certain m...

DNA Replication: A familiar ring to DNA polymerase processivity

Structural similarity reveals that prokaryotic and eukaryotic DNA polymerases share a mechanism for processivity--but the conservation of additional chromosomal replication mechanisms remains to be determined.

DNA polymerase I in constitutive stable DNA replication in Escherichia coli.

We examined the effects of mutations in the polA (encoding DNA polymerase I) and polB (DNA polymerase II) genes on inducible and constitutive stable DNA replication (iSDR and cSDR, respectively), the two alternative DNA replication systems of Escherichia coli. The polA25::miniTn10spc mutation severely inactivated cSDR, whereas polA1 mutants exhibited a significant extent of cSDR. cSDR required ...